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All patients had sinus rhythm on the ECG obtained at hospital discharge and were followed up 7 years.
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In CDC, mAbs interact with the C1q component of complement, leading to activation of the complement system and release of components (anaphylatoxins and opsonins) that can directly interact with receptors on immune cells (C3aR, C5aR, CR1, CR3) leading to their activation, migration and other effects.
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Between 1998 and 2000, 13 such cases were reported from France--12 in patients who had received the Eprex formulation of epoetin alfa and 1 in a patient who had received Neorecormon (a formulation of epoetin beta); both are products that are marketed outside the United States.
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In 1998, epoetin-associated pure red cell aplasia (PRCA) was first reported and causation was attributed to formulations without human serum albumin (HSA), subcutaneous administration, and uncoated rubber stoppers.
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